Monday, October 22, 2018

Oman Facility Management Market is Expected to Reach over USD 800 Million in terms of Revenue by 2022: Ken Research


Oman Facility Management market segmentation by Types of Services (Single, Bundled and Integrated Services), By Sectors (Commercial, Hospitality, Residential, Industries and other sectors), By In house and Outsourcing services and By Hard and Soft Services Company Profile of Oman Facility Management: Renaissance Contract Services Group, Al Naba Services, Oman International Group, Osco Oman, Como Facility Management Services, Bahwan Engineering, Kalhat Group, EFS Trading,  General Electric and Trading Co and Qurum Business Group.

·         Industrial sector has given a boost to the commercial sector in Oman with various projects developing in this sector, having a positive impact on the Oman Facility Management market.
·         The new hospitals, medical centers and clinics in the pipeline due to Oman’s Health Vision are expected to create opportunities for hard FM services industry and increase the demand in the coming years.
·         Computer Aided Facility Management software provides facility management companies with administrative real time information which help them to track, manage, report and plan assets and facilities.

Analysts at Ken Research in their latest publication Oman Facility Management Market Outlook to 2022 – By Soft Services (Housekeeping, Landscape Access and Façade Access, Security, Others) and By Hard Services (HVAC, Electromechanical, Operational and Maintenance, Fire Safety and Security)believe that the commercial sector in Oman has been growing and is expected to augment further given the 9th Five Year Development plan and Vision 2020 of the country. The market is expected to register a positive CAGR of 6.9% in terms of revenue during the forecast period 2018-2022E. The market is further expected to be driven by the rising competition from new companies entering the market.

The facility management market in Oman is fragmented which provide immense opportunity to global and local players to tap this market with the aid of technology advancements and rising awareness among Omanis towards FM services. Enormous growth in construction, tourism and healthcare industries in the country will increase the demand for FM services. Additionally, the 9th Year Development plan (2016-2020) is expected to trigger the demand for FM services owing to the increase in infrastructure projects. Oman National Development Plan (2016-20) has put a special focus on manufacturing, mining and tourism sector. These sectors are expected to attract huge investment from both private as well as public sector. Out of these sectors manufacturing sector is estimated to attract highest capital, close to USD 6.7 billion from 2016 to 2020.

The hospitality industry in Oman has been growing during the review with the rise in hotels and hospitals in the country due to increasing inflow of expats. The supreme council for planning has formed a committee in Oman to develop comprehensive green design code for the country in adherence to GCC building code. The construction of such buildings has increased the demand for facility management in the country.

Keywords:-
Facility Management Market in Oman
Oman Facility Management Revenue
Facility Management Services Industry
Oman Facility Management Growth
Soft Facility Management Market Oman
Oman Housekeeping Market
Cleaning Services Market in Oman
Housekeeping Services Market Oman
Major Companies Oman Facility Management
Facility Management Market Middle East
Facility Management Market GCC
Middle East Facility Management Association
Major Players Operating in Oman Facility Management
Facility Management Future Oman

Key Segments Covered:-
Soft and Hard Facility Management: Soft Services, Hard Services
Soft Services: Housekeeping, Landscape Access, Security
Hard Services: HVAC, Electromechanical Services, Operations and Maintenance, Fire Safety and Security
Type of Service: Single, Bundled, Integrated
Outsourcing and In House services
Sectors: Industrial and Public Infrastructure, Retail, Commercial, Hospitality, Residential and Others
Key Target Audience:- Facility Management Companies, Contractors, Commercial Offices, Hotels and Hospitals, Associations
Time Period Captured in the Report:-
Historical Period - 2011-2017
Forecast Period - 2018-2022E
Companies Covered:- Renaissance Contract Services Group, Al Naba Services, Oman International Group, Osco Oman, Como Facility Management Service, Bahwan Engineering, Kalhat Group, EFS Trading, General Electric and Trading Company, Qurum Business Group

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The report provides a comprehensive analysis of the facility management services in India. The report covers various aspects such as market size of India facility management market, segmentation on the basis of types of services, organized/unorganized, major cities, type of contracts, sectors of services provided and subsectors. The report also covers the market shares of major facility management companies in India as well as the revenues of major players in the facility management market along with future outlook, entry barriers and macro economic variables affecting the industry performance.

The report provides insight on hard and soft facility management market, growth drivers, trends and developments, competition and future analysis. The report also provides market share contributed by major service providers in Bahrain. The stakeholders of this report include Facility management service providers, companies involved in research, real estate and infrastructure developers in Bahrain and the new entrants and venture capitalists who wish to invest in Facility management market in future.

The report provides a comprehensive analysis on the facilities management market in Kuwait. The report covers various aspects such as overall size of Kuwait facilities management market size in terms of revenues, Market segmentation of Kuwait facilities management market on the basis of types of services, by integrated, bundled and single services, Business sectors, In-house & outsourcing, trends and growth drivers of the industry, issue & challenges, market share, and future analysis of the industry and segmentation, government regulatory. The report also covers the competitive landscape of the industry, list of upcoming infrastructure projects. The report serves as a benchmark for every new player which is seeking to enter into facilities management market in Kuwait.

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Thursday, October 18, 2018

Treatment Factors for Radiation Induced Nausea and Vomiting: Ken Research


Radiation-induced nausea and vomiting (RINV) is common occurrence in cancer patients treated with radiotherapy. The emetogenic potential of these radiations depends greatly on the location of the radiation field, the size of the radiation field and the fractionation scheme. It refers to a radiation sickness syndrome, which is characterized by a latent asymptomatic period 1–2 h after treatment. RINV could induce dehydration, malnutrition and electrolyte imbalance, which worsens patient’s quality of life and lead to treatment delays & cancellation.

According to study, “Radiation Induced Nausea and Vomiting (RINV) Global Clinical Trials Review, H1, 2018” some of the major companies that are currently working in the radiation induced nausea and vomiting are Vimta Labs Ltd, Insys Therapeutics Inc, A. MenariniIndustrieFarmaceuticheRiuniteSrl, RedHillBiopharma Ltd, IPCA Laboratories Ltd, Dr. Reddy's Laboratories Ltd, AurobindoPharma Ltd, APR Applied Pharma Research SA, Altasciences Company Inc, Accutest Research Laboratories (I) Pvt Ltd.
RINV can be defined by two phases of radiotherapy acute phase and delayed phase. The acute phase is defined as the first day of radiotherapy to one day after administration, whereas the delayed phase encompasses days 2–10 after treatment.

The RINV management include to prevent an initial emetic episode from occurring and to manage symptoms once they present as a result of radiotherapy. Some symptoms of RINV are nausea, vomiting, pallor, diaphoresis, salivation, anorexia, headaches, low urine output, dizziness and rapid heart rate. Some other symptoms include specially for the cancer patients such as constipation, bowel obstruction, gastroparesis, malignant ascites, anxiety, fluid & electrolyte imbalances, uraemia, metastases, liver or central nervous system, raised intracranial pressure, peptic ulcer disease, recent or concurrent chemotherapy and vestibular dysfunction. The occurrence of RINV is depending on radiotherapy-related factors such as the site of irradiation, the dosing, fractionation and irradiated volume and radiotherapy techniques.

RINV’s incidence and severity is depending on both treatment factors and patient related factors. Treatment related factors are site & volume of radiation, single & total dose and fractionation schedule whereas patient related factors are gender, age and concurrent or recent chemotherapy factors. The diagnosis of RINV is depend on many factors such as the frequency, intensity, onset & duration of vomiting, history & compliance with antiemetics, concomitant medications (e.g. opioids), hydration status, nutritional intake +/- weight loss, heartburn/dyspepsia, haematemesis and blood test etc.

The three major antiemetic guidelines exist that make RINV management recommendations, which are multinational association for supportive care in cancer (MASCC), American society of clinical oncology (ASCO) and the national comprehensive cancer network (NCCN). These guidelines divide the RINV risk into four categories based upon radiation field: high (risk>90%), moderate (risk 60 to 90%), low (risk 30 to 60%) and minimal (risk <30%). They also suggest strategies for prophylactic and rescue treatment as a function of the anatomic site being irradiated.

It is estimated that the incidence of RINV among patients undergoing radiotherapy is estimated at 50–80% and a small group of interested international investigators are emerging to coordinate future research goals in RINV. In upcoming years, by raising awareness of RINV as common clinical concerns, and educating patients about their options for prevention, a strong patient interest and advocacy movement is expected to be develop, which will ultimately be the most powerful motivator for progress in this field.

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Symptoms and Cure of Geographic Atrophy: Ken Research


Geography atrophy (GA) is a chronic disease, which leads to visual function loss. It is defined as a round or oval area of atrophy of 175 µm or more. It is the last stage of dry age-related macular degeneration (AMD) that can result in the progressive and irreversible loss of retina.
The initial symptom of GA may be found during reading, when one or several letters in a word are missing, or when looking at faces, a small part of the face cannot be seen. Some risk factors of GA are family history of AMD, smoke and increasing age.

GA is classified in two types drusen-related GA and neovascularization-related GA. Drusen related GA is the hallmark of ADM: it is seen as crystalline yellow or white dots that lie between the retinal pigment epithelium and membrane whereas the neovascular process leads to a plethora of cellular stresses such as ischemia, inflammation and dramatic changes in cell environment that further taxes retinal pigment epithelium cells already dysfunctional from drusen-associated changes.

According to study, Geographic Atrophy - Pipeline Review, H2 2018 some of the major companies that are currently working in the geographic atrophy are Achillion Pharmaceuticals Inc, AcucelaInc, Alkeus Pharmaceuticals Inc, Allergan Plc, Apellis Pharmaceuticals Inc, Cell Cure Neurosciences Ltd, Colby Pharmaceutical Co, F. Hoffmann-La Roche Ltd, Foamix Pharmaceuticals Ltd, Genentech Inc, GenSight Biologics SA, Ionis Pharmaceuticals Inc, Johnson & Johnson, Novartis AG, NovelMed Therapeutics Inc, Ophthotech Corp, Ra Pharmaceuticals Inc.

There are some diagnostic procedures are involved in GA, which are; autofluorescense,optical coherence tomography (OCT), multifocal electroretinography and ordinary measuring. Autofluorescense is an imaging technology to visualize the retinal pigment epithelium (RPE) in geographic atrophy: itprovides important information on expected progression rate through the amount of hyperfluorescense in the functional zone of the lesion.OCT can help early recognition of intraretinal fluid, which is important in order to start treatment and remain function. The atrophy of the retinal layers becomes very obvious by OCT technique. In multifocal electroretinography, a light stimulus is performed in patterns across the retina, and photoreceptor signaling is detected by an electrode. Ordinary measuring provides poor information on the actual function of the retina, due to foveal sparring and parafoveal scotomas, therefore microperimetry tools is used to evaluate all functions.

There is currently no proven treatment for GA. Patients can benefit from increased lighting, magnification and low vision devices that help with reading. However some medication involved for GA includes nutritional supplementation formula, neuroprotection and vasodilators. Nutritional supplementation formula consist by 80 mg zinc oxide, 2 mg cupric oxide, 15 mg β-carotene, 500 mg vitamin C and 400 IU vitamin En the different stages of AMD. In neuroprotection, two main drugs are used: brimonidine and ciliaryneurotrophic factor-501.In vasodilators, alprostadil, MC-1101, moxaverine and sildenafil drugs are used for treatment of GA. Some other drugs are underway in the treatment of GA for instance emixustat and fenretinide. Additionally, cell based therapy and APL-2 injections are also used for treatment of GA. Moreover, an implantable miniature telescope is also used for treatment of GA.

Nowadays there are two strategies are being explored to prevent the GA: photoreceptor & RPE preservation and inhibition of the complement cascade. Photoreceptors and the RPE are used to devise agents that ensure adequate circulation to the choroidal vasculature, thereby preventing apoptosis secondary to ischaemia. Lampalizumab is a monoclonal antibody fab fragment that inhibits complement factors and improves the efficacy of eculizumab in reducing the progression of GA AMD.

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Canada Plastic Pipes and Fitting Market Outlook to 2022: Ken Research

The report titled Canada Plastic Pipes and Fitting Market Outlook to 2022 - By PVC, UPVC, CPVC, PE (HDPE, MDPE, LDPE, PEX), PP, ABS, PVDF, PB Pipes, By Application (Water Supply and Sewage, Plumbing, Chemical, and Oil & Gas and Irrigation provides a comprehensive analysis of the Canada plastic pipe and fittings market. The report covers various aspects including introduction to Canada plastic pipe and fitting market size, major players, market segmentation by Type of Pipe (PVC, PE, Others), Market Segmentation by End User Application (Irrigation, Water Supply and Sewage, Plumbing, Chemical, Oil & Gas and Mining and Others), growth drivers, restraints, key regulations, future outlook and analyst recommendations.
Market Size
Canada plastic pipe and the fitting market is in its growth stage, witnessing consolidation with players increasing their market penetration through inorganic growth. The market has registered a single digit five-year CAGR from 2012 to 2017. The demand for plastic pipes and fittings is highly correlated with the investment of government on infrastructural, mining and agricultural activities and the demand for house dwellings in the country. Improvements in technology and plastic materials have helped plastic pipe increase its share in agriculture, and industrial sectors in Canada. The period witnessed an increase in usage of pipe relining technology. In this technology, old pipes mostly water supply and sewage pipes were refurbished by inserting PE pipes inside the already existing pipes. This allows the refurbishment process to happen without causing any major disruption in the infrastructure. The growth of this technology has resulted in an increase in demand for plastic pipes especially HDPE pipes in the market.
Market Segmentation
By Type of Pipes
The market is segmented into PVC, PE, and Others (plastic pipes such as ABS, PP, PVDF, and PB). In 2017, uPVC pipes had the largest market share as they are less costly then PE pipes and are widely used in various sectors such as water pipelines and sewage pipelines. In the PE segment, HDPE constitutes majority share in Canada. In other product segments, ABS-DWV (drain, waste, and vent) piping is used in single-family homes and general wood-frame construction. Durability, ease of installation and overall value of ABS in providing a plumbing drain system has made builders and contractors opt for this type of pipe.
By Market Structure
Manufacturers such as IPEX, ISCO, Uponor Infra, ADS, Aqua Q, Dura-Line are some of the players in organized sector manufacturing high-grade plastic pipes. They have a strong presence in various regions and have the partnership with all the major plastic pipes distributors and retailers in the country. The players in the unorganized market mostly manufacture limited products and would focus on a particular type of plastic pipes either PVC only or PE only and/or import other types of pipes and fittings from USA and Mexico in which they can exercise higher margins.
By Geographical Regions
The eastern Canada region accounted for the majority of the share because of the increased demand for house dwelling units in past few years and also due to the surging expenditure on various infrastructural and developmental activities and presence of various end-user industries. Most of the oil and gas industries in Canada are located near Alberta region as most of the oil reserves are located in this region. This is has resulted in huge demand for plastic pipes from oil and gas industries in Western Canada. In the Atlantic region, there was an influx of immigrant in this region leading to increases in population, which gave the boost to the construction activities in this region. Between 2016 and 2017, the population of Prince Edward Island increased to 150,000 marks for the first time.
By End-User Application
Most of the plastic pipes and fittings in Canada are used for water supply and sewage systems. UPVC and HDPE pipes are preferred by the government as they are comparatively low in cost as compared to steel and iron pipes. Plumbing which has the second highest share in the market has started using PEX pipes. Canada has been using copper pipes for plumbing application for years. However, in the last few years, PEX pipes have come up as a viable option to replace copper piping systems in certain applications. Polyethylene pipes have become the accepted standard for mining applications such as Solution Mining, Heap Leaching, Process Water, Process Slurry, Dust Suppression, Mine Dewatering. HDPE pipe has the toughness, structural performance, and resistance to abrasion and chemicals to withstand the unique stresses of mining applications.
Competition Scenario
The competition of the market is currently moving toward consolidation with major players eyeing at increasing market penetration through strategic partnerships or merger and acquisitions. IPEX, ISCO, Uponor Infra, ADS, Aqua Q, Dura-Line are some of the biggest manufacturers of plastic pipes and fittings in the country. Within the organized players, the price of the product tends to remain close to the industry prices and the manufacturers compete more on the basis of quality of the products and product availability in the wholesale and retail outlets and product customization at the time of bulk orders, whereas The unorganized players compete on the basis of price and the availability of the product in the retail and wholesale stores.
Future Outlook
The future outlook of the industry is positive with an estimated market size to grow at a CAGR of the single digit from 2017 to 2022. It is anticipated that the PE pipes will grow at the fastest pace among all the types of plastic pipes, due to the increase in acceptability across various other applications. The use of PVC pipes is expected to reduce due to substitution by other types of plastic pipes specifically PE pipes.
 Key Segments Covered
By End User Application:
  • Water Supply and Sewage
  • Irrigation
  • Plumbing
  • Chemical, Oil & Gas, Mining and Industrial
  • Others (Cable Protection, HVAC and other related industries)
By Type of Pipes:
  • PVC (CPVC and UPVC)
  • Polyethylene (PE) (HDPE, MDPE, LDPE)
  • Others (Include Polypropylene pipes, ABS, Polyvinylidene fluoride (PVDF), PB Etc.)
By Type of Market Structure
  • Organized Sector
  • Unorganized Sector
Key Target Audience
  • Plastic Resin Suppliers
  • Plastic Pipe and Fitting Manufacturing Companies
  • Oil and Gas Industry
  • Government Bodies
  • Real Estate developers
  • Agriculture Sector Companies
 Time Period Captured in the Report:
2012-2017 – Historical Period
2017-2022 – Future Forecast
Major Companies Covered:
IPEX Piping Systems, ISCO, Uponor Infra, ADS, Aqua Q, Polytubes, Dura-Line, CanPlas Plastics, Royal Building Products, Zenith Plastics, Rezplast Manufacturing Ltd, PVC Industrial Products Next Polymer and Bow Plastic and others
 Key Topics Covered in the Report
  • Overview of Canada Plastic Pipe and Fitting Market.
  • Value chain analysis.
  • Canada Plastic Pipe and Fitting Market Size by Revenue.
  • Major Players in the Canada Plastic Pipe and Fitting Market.
  • Market Segmentation by Type of Pipe (PVC, PE, and Others) and By End-User Application (Irrigation, Water Supply and Sewage, Plumbing, Chemical, Oil & Gas and Mining and Others)
  • Government Regulations and Standards.
  • Growth Drivers and Restraints
  • Company profile of Major Manufacturers (IPEX Piping Systems, ISCO, Uponor Infra, ADS, Aqua Q, Polytubes, Dura-Line, CanPlas Plastics, Royal Building Products, Zenith Plastics, Rezplast Manufacturing Ltd, PVC Industrial Products Next Polymer and Bow Plastic and others)
  • Export and Import Scenario in Canada Plastic Pipes and Fittings Market
  • Growth Drivers and Trends
  • Future Outlook
  • Analyst Recommendation.
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Policy and Incentives to Support UAE Power Market Development Research report : Ken Research


According to study, “UAE Power Market Outlook to 2030, Update 2018 - Market Trends, Regulations, and Competitive Landscape” some of the major companies that are currently working in the UAE power market are Abu Dhabi National Energy Company, Dubai Electricity and Water Authority, Sharjah Electricity and Water Authority, Federal Electricity and Water Authority, General Electric Company, Abu Dhabi Transmission &Despatch Company, Korea Electric Power Corporation, JinkoSolar Holding Co., Ltd.
There are many sources of energy such as natural gas, nuclear energy and solar energy. Renewable energy has a significant role in UAE’s energy matrix, accounting for more than 255 gigawatts of total power generation. The most important factor for the use of renewable energy is the power of government agencies to take holistic and comparative views of energy costs, in region. By the end of 2017, hydrocarbon based power generation accounts for approximately 98% of the total power generation capacity.
In UAE, one of the most important step towards improving electricity diversification and conservation is to develop smart grid and smart metering roll-out under the overall umbrells of demand side management. Additionally, a number of initiatives such as "smart electrical grid" and "smart meters" are developed. Smart electrical grid is responsible to encourage owners of houses and buildings in Dubai to use solar energy and sell the surplus to the government through the network itself. As well as, smart meters is responsible for contributing to rationalizing the consumption of electricity and water.
The project aims to encourage collaboration between the public and private sectors to achieve targets in six particular focus areas: smart life, smart society, smart transportation, smart governance, smart economy and smart environment. These projects are played an increasing role in power generation due to plummeting oil prices. This project strategy relies on three basic principles such as communication,integration and cooperation.
In 2017, in UAE, per capita electricity consumption is very high, at 13 mega-watt-hours. In Dubai and throughout the UAE, electricity price reforms are underway that are supportive of distributed generation.Nowadays, the UAE is encouraging the use of electric cars and building the necessary infrastructure to support power market. The UAE’s Vision 2021 focuses onfostering innovation in its power sector. Recently announced Dubai Clean EnergyStrategy 2050 aims to provide 7% of Dubai’s energy fromclean energy sources by 2020, 25% by 2030, and ultimately75% by 2050. The UAE, electricity price reformsare underway that are supportive of distributed generation and Dubaiclean energy strategy has a target for all rooftops in the city to producesolar energy by 2030.
It is expected that Dubai Clean Energy Strategy will be targeting for all rooftops in the city to produce solar energy by 2030.It is also estimated that renewable to 10% of the country's total energy mix, and 25% of total power generation, could generate annual savings of USD 1.9 billion by 2030 through avoidance of fossil-fuel consumption and lower energy costs. Additionally, the UAE plans to reduce energy imports and climate warming carbon dioxide emissions by 30% by 2030, using its solar power and nuclear power imported from Abu Dhabi, in order to reduce reliance on gas. It is estimated that, a 1000 megawatt solar plant will be build by 2030, which aims to turn to renewable energies for 25 percent of electricity needs.
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South Africa Crop Protection (Pesticides, Biopesticides, Rodenticides, Insecticides, Agrochemicals) Market Research Report: Ken Research


How South Africa Crop Protection Market is Positioned?
South Africa is one of the most developed countries in the African region. At present, South Africa is not only self-sufficient in virtually all major agricultural products but is also a net food exporter, which makes it 1 out of 6 countries in the world capable of exporting food on a regular basis. The crop protection market in South Africa is at a growing stage. South African crop protection market is dominated by imports. With no technical being manufactured in South Africa, the country has been majorly dependent on several countries for the procurement of technical which are used in crop protection. Majority of the global players have concentrated the crop protection market in South Africa. The presence of global players in the market has ensured that South Africa has access to quality products and innovations in the crop protection industry.

In terms of revenue, South Africa crop protection market generated gross revenue of ZAR ~ million in 2017. An increase in the number of resistant weeds and pests made crop protection companies to focus on bringing out newer and more effective herbicides and insecticides. Fungicides are still not used in an extensive manner. This is mainly due to the limited remedial measures that fungicides offer. Fungicides can only act against fungal infections and cannot control growth of pests or insects. In South Africa, the government regulations are strict and there are proper check points, at every stage of the sales process. This gives the government a control over the trading of crop protection products and as a result the market share of organized market is high.

South Africa Crop Protection Market Segmentation:-
By Market Structure:-
In South Africa, the government regulations are strict and there are proper check points, at every stage of the sales process. This gives the government a control over the trading of crop protection products and as a result the market share of organized market is high. The share of the organized market is said to increase in the future with government increasing the scrutiny and the various crop associations ensuring that farmers are purchasing crop protection products from legitimate means. This will also reduce the share of unorganized sector.

By Type of Pesticides:-
An increase in the number of resistant weeds and pests made crop protection companies to focus on bringing out newer and more effective herbicides and insecticides. The biopesticides market is still at a nascent stage with a huge potential to grow in the future. Farmers are still unfamiliar with biopesticides and their effectiveness. Since biopesticides leave little or no residue behind, with stricter Maximum Residue Level guidelines coming in, biopesticides is anticipated to grow in the future.

By Nature of Pesticides:-
Presently, the generic pesticides dominate the crop protection market. In the future, a lot of active ingredients are going to become off patent products. This is going to increase the number of generic pesticides in the market. The share of generic pesticides in the crop protection industry is said to remain constant in the future as well since we will also see an increase in the number of patented products.  The increase in number of patented products is due to increase in investment in research and development in biopesticides and investment into manufacturing conventional pesticides with lower residues.

By Form of Pesticides:-
Liquid pesticides have a majority share in the crop protection products as of 2017 in terms of revenues. Pesticides in liquid form are relatively easier to use and can be applied over the entire crop. Since the use of liquid pesticides is relatively easier, farmers prefer to use liquid pesticides. The pesticides in Granules and Powder form contain a mixture of 2 or more active ingredients with other chemicals mixed to form the pesticide. Granules and Powder form of pesticides are sold in fixed quantities per hectare making it easier for the farmer to apply the pesticides on the crop. The share of liquid and granules and powder form of pesticides are expected to remain the same in the future as well.

By Type of Crops:-
Cereal crops have contributed the most in the overall crop protection market on the basis of revenues with Maize contributing the most out of all the cereal crops. In case of Fruit crops, the pesticides are effective in combating against pests and increase the yield of the fruits. Vegetable crops such as potato, tomato and others are sprayed with pesticides thrice in different times. They are treated with fungicides during the growing season and with Herbicides before harvesting.

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Osteogenesis Imperfecta Disease Treatment Market Outlook, H2 2018: Ken Research

According to study, “Osteogenesis Imperfecta - Pipeline Review, H2 2018” some of the major companies that are working in the osteogenesis imperfecta are Amgen Inc, Bone Therapeutics SA, Genzyme Corp, Mario Biopharma Group Plc, Mesentech Inc, SOM Biotech SL.
OI is classified into many types based on clinical signs. Type 1 is the mildest type of OI. In type 1 includes triangular face, possible brittle teeth, minimal bone deformity, possible hearing loss, loose joint & muscle weakness, bones predisposed to fracture, a tendency toward spinal curvature etc. Type 2 is the most severe form of OI: it includes small stature, whites of eyes tinted, dominant autosomal, many times fatalities caused by deformed drugs. Type 3 is the most severe form of OI: it is defined by motor skill heights, motor skill delays, sunken or protruding chest wall, and very short height. Additionally, type 4 is similar to type 1 but with mild to moderate bone deformity: it includes scoliosis, white or blue sclera, large head, short height, and easy burnishing etc.
Osteogenesis imperfecta (OI) is a genetic disorder characterized by bones that break easily, often from little or no apparent cause, also called as “brittle bone disease”. It is caused by one of several genes that aren't working properly. It can also cause weak muscles, brittle teeth, a curved spine, and hearing loss. OI can range from mild to severe. Some other names of OI are lobster disease, blue-sclera syndrome and fragile bone disease. Some symptoms of OI are triangular –shaped face, short stature, hearing loss, brittle teeth, breathing problems and bone of deformities such as bowed legs of scoliosis. Some other symptoms of more severe forms of OI may include bowed legs & arms, kyphosis and scoliosis etc.
OI is one of the most common skeletal dysplasias and generalized disease of connective tissue. It may manifest itself with blue sclerae, hearing loss, scoliosis, joint laxity, barrel chest, triangular facies, macrocephaly, constipation & sweating, defective definition, limb deformities, fractures and growth retardation etc. It affects both bone quality and bone mass.
OI can affect various internal organs, leading to many major and secondary problems, which are lung problems, neurological problems, cardiac problems, thalassemia, abnormal blood coagulation, periodontitis, gastric function, basilar impression, kidney stones, vision, hearing, delayed healing, and bone mass & bone deformity etc.
There are some diagnostic methods are included in OI, which are histomorphometry, bone density measurement (BMD), ultrasound, radiography of the uterus, collagen analysis & genetic diagnosis. Histomorphometry is used for quantitative analysis of bone architecture, which provides valuable information on the amount of bone and its cellular activity. BMD test can measure bone density at the patient’s hip and spine. Ultrasound can be used to examine the fetal skeleton for bowing, fractures, shortening, or other bone abnormalities consistent with OI. Radiography of the uterus technique can detect the wormian bone and a single skull bone surrounded by sutures. Collagen analysis & genetic method is invasive and can cause injury to the infant or result in premature delivery and the reliability of genetic testing has relied on the development of new techniques such as electrophoresis and multiplex ligation-dependent probe amplification. Some other differential diagnoses are achondroplasia, glucocorticoid therapy & Cushing syndrome, homocystinuria, McCune- Albright syndrome, osteopetrosis & psteoporosis, rickets, scurvy, and Wilson disease.
There are many treatments are involved in OI such as surgical treatment, bisphosphonates, neridronate, teriparatide, and denosumab. Surgical treatment is mainly performed to correct deformities and to reduce the bone brittleness as the result of bad bowing and to improve the physical condition of the individual. Bisphosphonates drugs are responsible for reducing vertebral compressions and some long bone fractures. Neridronate can be administered both intravenously and intramuscularly, providing a useful system for administration in-home care for OI. Teriparatide drug decreases vertebral and non- vertebral fractures in post-menopausal women with osteoporosis. Denosumab decreases bone resorption, increases bone density, and reduces fractures in women with postmenopausal osteoporosis and also reduce the risk of bone-related events in patients with cancer that has spread to the bone. Some therapies are also used in the management of OI, which is; physical therapy, pharmacologic therapy, cell-based therapy, gene therapy, and stem cell transplantation therapy.
In recent years, many new genetic causes have been identified. In 2018, most genes cases of OI are COL1A1, COL1A2, CRTAP, and P3H1. In 2018, according to the investigation of many trials, teriparatide is used to increase bone strength as estimated by FE analysis in adults with mild OI. In upcoming years, gene therapy may be a possible future treatment option for severe OI.
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