Wednesday, August 1, 2018

Pakistan’s Typhoid Fever Outbreak To Supplement Research On Drug Resistant Bacteria Market Outlook: Ken Research


Typhoid is a bacterial infection that can lead to a high fever called Typhoid fever. It can also include instances of diarrhea and vomiting. It is caused by the Salmonella Typhi bacteria which gets deposited in food or water by human carriers and is then spread to others. This contaminated water and food is the most common channel for the spread of the infection.
According to the study, ‘TYPHOID FEVER – PIPELINE REVIEW, H2 2018, if detected early enough then typhoid can be successfully treated with antibiotics or else it can prove to be fatal as reported in one-fourth of the cases. Typhoid fever has been found to be common in low income countries. This fact further gains momentum by the results from various studies conducted on the cases reported in the US which reveal that three-fourth of them start when people travel internationally. Apart from the US, European countries also report encountering typhoid mostly when they visited Asia and South America. Countries such as Pakistan, India and Bangladesh are at the core of this argument as most of these countries suffer from poor sanitation and lack of access to clean drinking water. The risk of developing the infection is also there in visiting Africa.
Antibiotics are used to treat typhoid fever with the most common ones being ciprofloxacin and ceftriaxone. As with a number of other bacterial diseases, there is currently concern about the growing resistance of Salmonella Typhi against antibiotics. This concern is a very valid one as it is not only impacting the choice of drugs available to treat typhoid but also because this is not the first time the bacteria has shown resistance. In recent years, for example, typhoid became resistant air travel from Pakistan. Genomic comparison revealed that the person was carrying the outbreak’s infections. The subject was isolated and has now been treated. This study shows the typhoid strain causing the outbreak acquired an additional piece of DNA to become resistant to multiple antibiotics, including a third-generation antibiotic. The team also discovered that the typhoid outbreak was caused by strain H58, a strain known to be associated with multidrug resistance. When researchers looked further they discovered that the strain of H58 had gained an extra strand of bacterial DNA that provided additional antibiotic resistance genes.
Recent research results published suggest that treatment options are running out for typhoid fever and there is an urgent need for preventive strategies including vaccines.More developed parts of the world such as Europe and the US report small number of cases compared to the hubs such as South Asian nations particularly, as demonstrated by Pakistan. Better hygienic conditions can greatly assist the curing and treatment options available.
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