Indocyanine green (ICG), cyanine dye is
largely used for the medical diagnostics. It is alsousefor determining cardiac
output, liver and digestive blood flow, hepatic function, and for ophthalmic
angiography. ICG has a highest spectral interest at about 800 nm. It alsohas a
water-solvable, tricarbocyanine dye by molecular weight of 775 daltonswhich
isapproximately complete protein-bound (98%) after its injection into vein. The
withholding of ICG in the choroidal circulation, attached with low
permeability, and kindsof ICG angiography perfect for imaging of thechoroidal
circulation. The ICG is further absorbed in the liver and emitted into the
bile.
The IR frequencies enterinto retinal layers,
permitting ICG angiography to copy deeper patterns of flowassociated to
fluorescein angiography. ICG resolvesfirmly to plasma proteins and becomes thin
to the vascular system. It has a half-life of 150 to 180 seconds & is
detached from flow exclusively by the liver to bile juice. Indocyanine green
stains the frontal capsule and inner preventive membwrane of eye to enable its
removal. However, safety of intraocular indocyanine is still of distress
Atheoreticbenefit of ICG is its capability to
fluoresce enhanced through pigment, fluid, lipid, and hemorrhage than
fluorescein dye, thusgrowing the opportunity of noticinganomalies such as CNV
which mayget choked by a thinlayer of subretinal hemorrhage or hyperplastic RPE
on a fluorescein angiogram.
According to study, “Global
Indocyanine Green Market Status (2015-2019) and Forecast (2020-2024) by
Region, Product Type & End-Use” the key companies operating in the global
indocyanine green market areAkorn, Incorporated,Diagnostic Green GmbH,Aurolab,
Daiichi Sankyo Company, Limited,H.W. Sands Corp., SERB, Iris Biotech
GmbH,Dandong Yichuang Pharmaceutical Co., Ltd., Sigma-Aldrich Corporation,
Pulsion Medical Systems.
Based on product type, indocyanine green
market is segmented into pharma grade and others. Based on dosage
consideration, market is segmented into renal impairment and hepatic
impairment. Based on route of administration, market is segmented into
interstitial cervical injection and intravenous bolus injection. Based on
end-users, market is segmented into children, neonates & infants and adults.
In addition, based on application, market is segmented into neurosurgery,
ophthalmology angiography diagnostics, liver diseases and others.
The indocyanine green market is largely driven
by upsurge in number of patients undergoing ophthalmic angiography, followed by
increase in usage in medical diagnostics. However, anaphylaxis or other
allergic reactions rate in people with iodine hypersensitivity may affectthe
market. Moreover,upsurge in chances in developing economies andgrowth in
healthcare industry are key opportunities for market. Furthermore, rise in
healthcare outlay by consumers is a major drift for market. Risein cases of
obesity all over the globe, coupled withrise in binge eating and eating of junk
foods, negligence towards consistent exercising, rising levels of pressure, are
further supporting the demand of ICG over the forecast period.
The tendency for the demand of indocyanine
green segment is likely to grow at a greater CAGR over the forecast period
owing to being the only permitted fluorescent dye for clinical use as thekey
products such as SPY elite, PINPOINT, and SPY-PHI. Also, ICG is the
cost-effective and has potentially no adversative effects.
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