According
to the study, ‘PERIPHERAL T-CELL LYMPHOMAS (PTCL) GLOBAL CLINICAL
TRIALS REVIEW, H1, 2018’, cancer treatment around the world is improving
rapidly and lymphatic cancer is no exception despite the exact causes of
peripheral T-cell lymphoma being currently unknown. However, the cancer is
believed to be associated with the exposure to viruses such as the human T-cell
leukemia virus-1 (HTLV-1). Presently available treatment includes chemotherapy,
localized radiotherapy, stem cell transplants and steroid therapy. New
treatment options are also being explored and experimented. Understanding the
causes of PTCL has been a major contributor to this new development.
Lymphoma
is a cancer of the lymphatic system which affects a type of white blood cell
known as lymphocytes that help fight diseases in the body. T-cell is a type of white blood cell that
is of key importance to the immune system that triggers the body’s response to
certain pathogens. A similar lymphocyte called Natural Killer (NK) cell shares
many features with T-cells. When NK cells become cancerous, the cancer is
called NK or T-cell lymphoma and develops in lymphoid tissue such as the lymph
nodes and spleen. Peripheral T-cell lymphoma (PTCL) is defined as a diverse
group of aggressive lymphomas that develop from mature stage white blood cells called
T-cells and NK cells.
In
May 2018, the American Society of Clinical Oncology (ASCO) announced chimeric
antigen receptor (CAR) T-cell therapy as Advance of The Year for 2018. CAR
T-cell therapy is a type of treatment in which a patient’s T-cells are changed
in the laboratory such that they will attack cancer cells. T-cells are taken
from a patient’s blood and then the gene for a special receptor that binds to the
CD-19 protein on the cancer cells is added in the laboratory. This special receptor is called CAR. Large
numbers of CAR T-cells are grown in the laboratory and are given to the patient
by infusion.
In
2017 also there were major triumphs for this technology as the year saw some
major developments regarding the same. Two CAR T-cell therapies were approved
by the US FDA, one for the treatment of children with acute lymphoblastic
leukemia and the other for adults with advanced lymphomas. These clinical successes
are part of a rapidly emerging immunotherapy approach which is called adoptive
cell transfer (ACT) which is collecting and altering the patient’s own immune
cells to treat their cancer. There are several types of ACT but the one that
has advanced the furthest in clinical development is CAR T-cell therapy.
This approach is currently being seen as a
means to transform cancer care as it represents an exciting innovation. CAR
T-cell therapy is clinically the most advanced of the adoptive cell transfer
(ACT) class of immunotherapy and has primarily been used in patients with
advanced blood cancer. Nevertheless, researchers are still developing the field
of ACT in order to expand their effectiveness against solid tumors such as
breast and colorectal cancer. Immunotherapy is continuously innovating and
developments like CAR T-cells cement this fact with present operative capacity
in lymphatic sectors. Many more CAR T-cell clinical trials are currently
underway and further substantial progress is expected in the next few years.
To
know more, click on the link below:
https://www.kenresearch.com/healthcare/general-healthcare/peripheral-t-cell-lymphomas/150994-91.html
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